SkinVive, Korean’s go-to skin booster injection for flawless skin.

This content introduces the SkinVive skin booster, which is gaining popularity in Korea for its ability to restore the skin’s regenerative cycle and promote healthy, glowing skin. It explains how aging and sun exposure not only affect the skin’s surface but also impact essential components like hyaluronic acid, collagen, and elastin. While there are many skin-boosting injection treatments, such as Glass Skin Injection (hyaluronic acid injection), Rejuran Healer, and Juvelook skin, finding the most suitable option for your skin is key. Today, we’ll explore the principles, benefits, and pricing of SkinVive at the best skin clinic, Girin Plastic Surgery.

1. The origin of SkinVive

SkinVive started from Allergan’s Juvéderm Volite, which is commonly known as a filler. However, unlike traditional fillers, SkinVive is classified as a skin booster. The treatment involves directly injecting hyaluronic acid, which is excellent at retaining moisture, into the dermal layer of the skin. 

Hyaluronic acid is one of the key substances affecting skin aging, and it plays a vital role in maintaining moisture levels and improving skin structure. SkinVive stands out because it combines the benefits of both fillers and skin boosters, while significantly reducing the risk of side effects that are typically associated with fillers, such as nodules (A small lump) or granulomas.

This approach makes SkinVive a highly effective and safer option for those seeking to rejuvenate their skin without the common complications seen in traditional filler treatments.

2. Hyaluronic Acid base Skin Booster

The skin is divided into two main layers: the epidermis and the dermis. The dermis consists of cells and the extracellular matrix (ECM). The three key cells in the dermis are fibroblasts, which produce collagen and elastin, immune cells responsible for immune functions, and the outer skin is formed by cells called keratinocytes.  The ECM is made up of fibers like collagen and elastin, and These substances can be broadly classified as the amorphous ground substance, a type of GAGs (glycosaminoglycans) that serves as the background in which these components exist.

One of the main components of GAGs is hyaluronic acid, which attracts and retains moisture. This is essential for maintaining the structure of collagen and elastin, creating an environment that supports their presence in the skin.

Skin cells rely on capillaries to deliver essential substances such as hormones, growth factors, and oxygen, while also removing waste, reactive oxygen species, and carbon dioxide. These metabolic processes occur within the environment created by hyaluronic acid in the skin.

SkinVive is made up of collagen, elastin, GAGs (which help retain moisture), and aquaporin-3. Recent studies have shown that when SkinVive is injected, it increases the production of aquaporin-3 (a transport protein for water and glycerol), leading to increased hydration of the skin's surface. 

It also promotes the formation of SDF-1 protein, which inhibits melanin production, resulting in brighter skin tone. This additional benefit has contributed to SkinVive being known in Korea as a long-lasting skin booster with no risk of lump formation, making it a highly trusted treatment.

3. Four Studies on the Effects of SkinVive

1) Randomized, Multicenter, Evaluator-Blind, Delayed-Treatment Controlled Study in 14 Clinics in the United States

The study "A Randomized, Multicenter, Evaluator-Blind Study to Evaluate the Safety and Effectiveness of VYC-12L Treatment for Skin Quality Improvements", published in Dermatologic Surgery (49(7): p. 682-688, July 2023), was a large-scale, multi-center research conducted in the United States.

This study aimed to assess the effectiveness of SkinVive (VYC-12L) by evaluating patients over a set period after treatment. Researchers examined improvements in skin quality while ensuring a rigorous evaluation process through a randomized and blinded methodology.

Reference:
Alexiades, Macrene MD, PhD*,†; Palm, Melanie D. MD‡; Kaufman-Janette, Joely MD; Papel, Ira MD; Cross, Sarah J. PhD; Abrams, Steve MD; Chawla, Smita PhD. A Randomized, Multicenter, Evaluator-Blind Study to Evaluate the Safety and Effectiveness of VYC-12L Treatment for Skin Quality Improvements. Dermatologic Surgery 49(7): p. 682-688, July 2023. | DOI: 10.1097/DSS.0000000000003802

Participants in the study were divided into two groups: VYC-12L (SkinVive) and Delayed Treatment Control (DTC), with a 2:1 random allocation.

• VYC-12L Group: Participants in this group received initial treatment and optional additional sessions as necessary to achieve optimal treatment results. These treatments were administered within a month.
• DTC Group: Participants in this group were monitored for one month after random assignment and then either completed the study or received delayed treatment with optional adjustments as needed.

Both groups underwent safety evaluations 3 days after treatment, and effectiveness evaluation was assessed at 1st, 2nd, 4th, and 6th months after the final injection by follow-up observations.

A total of 90 participants completed the ACSS (Assessment of Cheek Softness Score) validation, and 92 participants completed the AFLS (Assessment of Fine Lines and Wrinkles) validation. 

Most participants in both studies were women (ACSS: 52.2%; AFLS: 53.3%) and of Caucasian descent (ACSS: 81.1%; AFLS: 79.3%), with minimal representation of Hispanic or Latino participants (ACSS: 93.3%; AFLS: 89.1%).

The participants had Fitzpatrick skin types III (ACSS: 36.7%; AFLS: 37.0%) and IV (ACSS: 25.6%; AFLS: 26.1%). The average age of participants was 54.0 years in the ACSS study and 52.5 years in the AFLS study.

A total of 4 mL of the treatment was injected, covering areas from the tear trough to the jawline, and the softness of the cheeks was evaluated. One month after treatment, the ACSS score for cheek softness improved by at least 1 point in the experimental group, showing significantly better results compared to the control group. In the AFLS wrinkle evaluation, the experimental group also showed a significantly higher rate of improvement (more than 1 point) compared to the control group a month after the injection.

As for side effects, fewer than 2% of participants experienced any adverse reactions, such as headaches or acne. Post-treatment reactions were mostly mild, such as itching or redness. One participant had significant bruising, which resolved on its own without treatment. Another participant developed a small rash at the injection site after a touch-up treatment, which disappeared by the time the study concluded.

2) Skin Condition Improvement with the New Injectable Hyaluronic Acid VYC-12 (SkinVive): Objective Results Using Digital Analysis

Reference:
Cavallini, Maurizio MD*; Papagni, Marco MD*; Ryder, Timothy J. DPhil†; Patalano, Mariagrazia MD, PhD‡. Skin Quality Improvement With VYC-12, a New Injectable Hyaluronic Acid: Objective Results Using Digital Analysis. Dermatologic Surgery 45(12): p. 1598-1604, December 2019. | DOI: 10.1097/DSS.0000000000001932

This study, published in 2019, digitally analyzed the results of SkinVive injections on various facial wrinkles. It was a prospective, non-randomized, open-label, single-group study conducted at two centers in Italy. The study included 40 female participants with fine facial wrinkles, low hydration, dull tone, and signs of aging and photoaging.

The treatment was administered at a 45° angle using a 32G/13mm needle to inject into the deep dermal layer, without the use of local anesthesia before the procedure. A total of 2 ml of VYC-12 (SkinVive) was injected in a single session into areas such as the cheeks, around the mouth, and the glabella lines (if necessary), at the deep dermal layer or sub-dermal layer. An additional 1 ml was injected into the neck wrinkles if required.

The average age of the 40 participants was 48.3 years, and they all completed the study. The average amount injected was 2-3 ml in a single session. The data analysis showed that VYC-12 improved fine wrinkles and skin texture. After 45 days and 6 months, the skin texture improvements were most noticeable on the cheeks and around the mouth. Although improvements were also observed in the glabella lines, but statistical analysis was limited due to the smaller sample size in this area.

3) Classification of Cheek Wrinkles Based on Causes and Non-Surgical Treatment Options

Reference:
Peng J-H, Peng H-L. Cheek Wrinkles Revisited: Etiological Classifications and Nonsurgical Treatment Options. J Cosmet Dermatol. 2023; 22: 1733-1738. doi:10.1111/jocd.15689

The study, published in 2023, classifies cheek wrinkles and introduces corresponding treatments for each type. Five different types of cheek wrinkles are described: atrophic wrinkles, dynamic expression wrinkles, static expression wrinkles, relaxed wrinkles, and sleep wrinkles.

① Improved Type 5 Wrinkles (Sleep Wrinkles) with VYC-12 (SkinVive)

Sleep wrinkles are formed by repetitive compression and the tension and shear forces acting on the cheeks when sleeping in certain positions, particularly on the side. In this study, a 63-year-old Southeast Asian male with sleep wrinkles used 1 ml of SkinVive (VYC-12), which led to improvement in the appearance of his sleep-related cheek wrinkles.

② Treatment Methods for Volume Restoration by Type of Wrinkle

• Type 1: Atrophic Wrinkles
  Atrophic wrinkles are accompanied by a loss of volume in a large area, so treatment should involve hyaluronic acid fillers to restore volume and smooth out the skin.

• Type 2: Dynamic Expression Wrinkles
  Dynamic wrinkles are caused by excessive muscle activity, so treatment requires botulinum toxin (Botox) or hyaluronic acid fillers to relax the muscles and smooth the wrinkles

• Type 4: Relaxed Wrinkles
  Relaxed wrinkles are associated with a decline in skin quality over a broad area, making treatments like Ultherapy (Ultrasound lifting) particularly suitable for tightening and improving skin texture.

• Type 3: Static Expression Wrinkles and Type 5: Sleep Wrinkles
  Both static expression wrinkles and sleep wrinkles involve localized patterns of skin creases, which can be treated with small amounts of subcutaneous filler injections or laser lifting techniques.

4) Clinical Experience at a Brazilian Clinic

Reference:
Dal'Asta Coimbra D. Clinical Experience with a New Injectable Hyaluronic Acid Designed to Improve Skin Quality in a Private Clinic in Brazil: A Retrospective Cohort Study. Health Sci Rep. 2021; 4:e399. doi:10.1002/hsr2.399

his study focuses on patients treated with Juvéderm Volite (SkinVive) from May 2018 to October 2019 in Rio de Janeiro. The data was collected from the primary physician's records at each clinical visit.

A total of 108 patients received Juvéderm Volite hyaluronic acid gel injections, with 159 treatment sessions in total. The average follow-up period was 300.3 days.

Needle-based injections accounted for 116 sessions (73%), while cannula-based injections (25G, 27G, 30G) were used in 58 sessions (36.5%). In 15 sessions (9.4%), both needle and cannula were used. 66.7% of patients received 1ml of Volite per session. Among patients treated with needles, 57.8% received 1ml per session, and 75.9% of patients treated with a cannula received the same amount.

93.8% of those receiving 1ml of Volite per session were under 40 years old and the treatment areas were as follows:

• 45.9% of patients received treatment around the mouth.
• 28.9% on the sides of the face.
• 13.8% on the lips.
• 10.1% on the neck and lower eyelid area.
• 9.4% on the eye area and décolleté.

Areas most frequently requiring touch-up treatments were around the eye area (15.4%) and mouth area (15.1%).

The average time between additional treatments was:

• 1.5 months for side face treatments,
• 2.6 months for lower eyelid area treatments.
• Re-treatment was mostly needed in the following areas:
• 20% of patients required re-treatment for the forehead,
• 17.6% for the face.

The average intervals for re-treatment were:

• 3.9 months for the décolleté,
• 6.7 months for the forehead.

Regarding safety, no significant complications like visible lumps, nodules, or delayed hypersensitivity reactions were observed during the 300.3-day follow-up period.

5) Summary

SkinVive effectively improves skin texture damaged by aging and can reduce wrinkles (both static and sleep wrinkles). It can be used on areas such as the forehead, frown, glabella lines, cheeks, eyes, mouth, neck, and décolleté, with treatment amounts ranging from 1ml to 4ml depending on the area and purpose. As age increases, additional sessions may be required, with intervals ranging from 1.5 months to 6 months.

4. Benefits of SkinVive

1) Minimal Pain

SkinVive uses thin needles (32G) and contains lidocaine, a local anesthetic. This makes it a great choice for individuals who are sensitive to pain or who are looking to experience skin boosting in Korea with minimal discomfort.

2) FDA-Approved Hyaluronic Acid

It helps with hydration, brightens the skin tone, enhances skin texture, and increases elasticity. It also temporarily improves fine lines, especially around the cheeks.

5. Recommended Candidates for SkinVive

Hydrated skin is characterized by enhanced elasticity, a bright skin tone, and diminished fine lines. SkinVive has been recognized for its temporary improvement in fine lines around the cheeks. Additionally, it promotes a soft skin texture, provides moisture, improves pore appearance and elasticity, and helps balance oil and moisture levels, benefiting conditions like acne and dermatitis.

SkinVive is recommended for individuals with the following skin concerns:

• Dehydrated oily skin
• Concerns about small pimples or acne
• Extremely dry and sensitive skin
• Loss of skin elasticity due to excessive dryness
• General skin condition enhancement

This makes it an excellent treatment option for anyone looking to improve skin quality and hydration, especially in Korea’s best skin clinics.

6. Difference Between SkinVive and Other Skin Boosters

1) Longer Lasting Effects

SkinVive features a cross-linked structure of hyaluronic acid molecules, which slows down the absorption and breakdown process in the body. Typically, skin booster injections at renowned clinics in Seoul require three sessions at 2- to 3-week intervals, with effects lasting around six months. However, SkinVive provides results that last over six months with just a single session—extending its longevity by more than 50%.

2) No Visible Bumps After Treatment

Skin Botox treatments like Juvelook and Rejuran often leave temporary bumps due to their shallow injection depth and gradual absorption process. Many Korean skin booster treatment videos on social media highlight this effect, showing how the bumps subside within 2–3 days.

In contrast, SkinVive is injected into the deeper dermal layers, preventing visible bumps from forming. This makes it an excellent option for those visiting Korea who want a skin treatment without worrying about downtime, ensuring a seamless post-treatment experience.

In most of the skin clinics in Seoul, the price of SkinVive ranges from 200,000 to 500,000 KRW per 1cc. While it may seem relatively high, the longevity of results makes it a worthwhile investment. However, prices can vary depending on the clinic, promotional offers, and the expertise of the practitioner, so it’s essential to check the exact pricing before choosing the skin clinics and proceeding with treatment.

7. Treatments That Enhance SkinVive’s Effects

1) Thermage

Thermage is a lifting procedure that uses radiofrequency energy to stimulate collagen production deep within the skin. Many Korean celebrities credit Thermage as their secret to maintaining youthful skin, making it a highly popular treatment. By thickening and rejuvenating the skin, Thermage helps SkinVive retain moisture for a longer period, maximizing hydration and enhancing skin plumpness.

2) Dermotoxin (Skin Botox)

Dermotoxin is superficial Botox injection that smooths out fine lines and regulates sebum production. When combined with SkinVive, the hydrating effects counteract dryness, ensuring a more balanced and youthful appearance. Since Dermotoxin can sometimes lead to temporary dryness, pairing it with SkinVive prevents dehydration while enhancing wrinkle improvement.

3) Pigmentation Treatments & Laser Toning

Laser toning breaks down melanin, helping to reduce hyperpigmentation, sunspots, and freckles. After laser treatments, SkinVive boosts hydration, soothes irritation, and accelerates skin recovery. Additionally, well-hydrated skin responds better to laser treatments, making this combination especially effective.

8. Post-Treatment Care

Getting SkinVive at one of Korea’s best skin clinics isn’t the final step—proper aftercare is essential to maximize results and minimize side effects.

1) LDM Ultrasound Therapy

• Helps soothe irritated skin after injections.
• Ensures even distribution of SkinVive particles within the skin.

2) Self Care

• Cleansing: You can wash your face 4 hours after the procedure.
• Makeup: You can put makeup 12 hours after the treatment.
• Moisturizing: Apply hydrating and repair creams frequently to support skin recovery.
• Sun Protection: Always wear sunscreen to protect your skin from UV damage.
• Soothing Care: If your skin feels red or sensitive, use a cooling facial mask to calm irritation.

3) Post-Treatment Precautions

• Avoid saunas, intense workouts, alcohol, and smoking for 1 week.
• Refrain from exfoliating products or chemical peels for 2 weeks.
• Avoid anti-aging and whitening skincare products for 2 weeks.
• Watch for rare side effects:
  • Persistent swelling could indicate a hyaluronic acid allergy, though it’s uncommon.
  • In some cases, glass skin injections or HA fillers may cause severe swelling.
  • If swelling occurs only in the treated area or extends to hands and feet, consult a doctor immediately.

We’ve explored one of Korea’s most popular skin boosters, SkinVive. With so many decent skin clinics in Korea offering varying prices and services, it’s crucial to do thorough research. For the most accurate information, contact Girin Plastic Surgery, one of the best skin clinic in Korea.